Case Study: Therapy-related Acute Myeloid Leukemia: A Three-case Review

ABSTRACT Three patients were diagnosed at our facility with therapy-related acute myeloid leukemia (t-AML) but had differing etiologies. Patient A was a 30-year-old male history of lymphoblastic in remission. The patient admitted to the hospital early 2019 for pain control and concurrent pancytopenia. bone marrow biopsy performed because concern relapsed disease. showed 96.6% blasts 95% cellular. different immunophenotype comparison his original diagnosis now monocytic nature. B 63-year-old complex medical who severe thrombocytopenia. determine cause cytopenia. report came back initially as myelodysplastic changes later changed after it discovered been taking cytotoxic agent kidney transplant. C started monitoring cytopenia 2016 distant B-cell non-Hodgkin’s lymphoma. Monitoring recommended repeated marrows until late 2017 when syndrome made. then evolved fall blast count passed 20%. Therapy-related is thought make up 5%–20% all syndrome/acute (AML) cases according National Comprehensive Cancer Network Acute Leukemia guidelines. number diseases can proceed t-AML, including breast cancer, gynecologic cancers, lymphoproliferative disorders. Certain drug classes are also known t-AML. t-AML have reduced rates relapse-free survival overall de novo AML.